Denamarin For Dogs: Dosage Chart by Weight

Dogs’ health should be a priority for every pet owner. The ratio of liver illnesses in dogs increases day by day around the world.

Canine liver illnesses require proper and timely treatment. Delaying can lead to severe health issues. Denamarin for dogs is among the proven veterinary medications to support canine liver function.

The most common brand name of veterinary Denamarin® is Protixin and Nutramax.

This Blog article is a comprehensive guide about Denamarin for canines, its benefits, possible side effects, safe serving ideas, and more.

You can use the table of content for quick navigation.. 

How Does Denamarin Help Dogs?

Denamarin for liver treatment

Denamarin is a proven veterinary liver support medication that contains active ingredients SAMe and Silybin that can aid the canine liver in a tonic way.

The SAMe (S-adenosylmethionine) help in liver cell repair and Silybin stimulates bile flow and helps protect against oxidative stress.

Denamarin work is a shield against liver illnesses and helps maintain a healthy liver function.

How much Denamarin for Dogs?

Denamarin usually comes in three standardized tablet forms: small, medium, and large. The small tablet is suggested for puppies weight up to 5 kg, Medium size tablet for dogs weighing 5-15 kg, and large size tablet for adult dogs weighing above 15 kg.

dog liver

Denamarin for Large Dogs: Large Table contain SAMe 425mg and silybin 35mg. 

Denamarin for medium-sized dogs: Medium Tablet contains SAMe 225 mg and silybin 24 mg.

Denamarin for small dogs: Small Tablet contains SAMe 90 mg and silybin 9 mg.

Denamarin Dosage chart for dogs by weight

Dog Weight in KgDog Weight in lbsDenamarin Dosage (Once Daily)
2-5 kg4-11 lbs1 Small Tablet
6-15 kg13-33 lbs1 medium Tablet
16-30 Kg35-66 lbs1 Large Tablet
31-55 Kg68-121 lbs2 Large Tablets
56 kg & Above123 lbs & Above3 Large Tablets


  • Helps to maintain canine liver function and health.
  • Repair the damaged cell and helps to produce new healthy liver cells.
  • Stimulates bile flow in the liver and protects against oxidative stress 

Side Effects

Giving Denamarin to your canine friend in a safe dose is safe. However, overdosing is toxic and can lead your pooch to stomach upset, vomiting, diarrhea, and even constipation.

Dogs who are allergic to the medication can develop the symptoms, too, even ingesting the safe dose. Contact your veterinarian before offering the denamarain to your pet. 

Denamarin interaction with other Medication

As with any other veterinary drug, Denamarin may interact too with certain medications. If your dog is on the below-mentioned medication, dont give Denamarin parallel with it simultaneously.

Contact your veterinarian for advice on the dosage duration gap.

  • Marin® or Marin® 
  • Tramadol
  • Dextromethorphan
  • Meperidine
  • Selegiline
  • Fluoxetine
  • Amitriptyline
  • Clomipramine 
  • Warfarin
  • Verapamil
  • Diazepam. 
  • Other antidepressant medications

If you notice any side effects or behavior changes, stop giving the medication and contact your veterinarian as soon as possible. 

How to Give Denamarin to dogs?

  • Carefully read medicine packaging, labels, and instruction before use for safety purposes.
  • Always give the correct form of the Denamarin tablet to your puppy E.g: Small, medium, or large tablet.
  • Follow the dosage instruction and never overdose.
  • Never crush the Denamarin. It can be harmful and dangerous.
  • Give the medicine on an empty stomach, 2-3 hours before meal.
  • Don’t feed your pup immediately after administering the Denamarin; hold the food for at least one hour.
  • Ensure to follow your vet’s instructions. Self-medication and self-treatment can be fatal.
  • If you observe any adverse reaction, stop giving the medicine and contact your veterinarian for gentle advice. 

How long should a dog take denamarin?

For the best result, you can give denamarin to your dogs once daily for 7-15 days on an empty stomach. Some pets may take longer to show the results. Your vet can increase or decrease the duration of the medication for your puppy.

What happens if you give Denamarin with food?

Giving the denamarin with food affects the absorption of S-Adenosylmethionine in the body and results in the medicine loss.

For the best result of the Denamarin, this is essential to give it on an empty stomach.

How long after Denamarin can I feed my dog?

If you have administrated the Denamarin to your canine friend, don’t offer the food immediately. Feeding your dog directly or quickly can affect the effectiveness of the medicine.

So it is best to hold the canine meal for at least 1 hour after giving the medication. 

Is it OK to crush Denamarin?

Never crush the Denamarin tablet. For the correct dose, you can choose a suitable form of the medicine, the small, medium, or a large form of the tablet for your pet.

Cutting the Denamarin pill can increase the toxicity risk and multiply the medication’s effectiveness by zero.

Is Denamarin the same as milk thistle?

There are only ingredients difference between Denamarin and milk thistle. The Denamarin contains two active ingredients, SAMe and Silybin, while the milk thistle only contains the active ingredient Silybin.

Can I give Denamarin every other day?

The duration of administration of Denamarin can depend on the severity of the liver issues. In some cases, veterinarians may prescribe the medicine for everyday use.

However, when improvement is observed, your veterinarian may advise administering the medication every second or third day. 

You May Also Like To Read:


Is cheese bad for dogs with liver illness?

Yes, cheese contains a rich fat content that is not safe for canines having health issues. Ingesting excess amounts of fat can increase the risk of pancreatitis in dogs.

Can your mix denamarin with food for dogs?

No, Denamarin should be administrated with an empty stomach. Mixing the drug with the food can affect the absorption of the medicine and can also develop allergic reactions and stomach upset such as vomiting and diarrhea. 

Can a dog recover from liver damage?

Yes, with the proper and timely treatment under the supervision of a professional veterinarian, a dog can recover from liver damage in the early stage. However,  recovery becomes difficult in severe conditions but can be controlled with treatment.

Thanks for Reading. If you Have any questions, please let us know in the comment section below. We will respond shortly.

Leave a Comment

Your email address will not be published. Required fields are marked *