PG 600 Dosage For Dogs? How & When to Use

PG means Progesterone, which is a hormone that plays a vital role in the reproductive cycle of dogs. During the estrus or heat period, levels of progesterone rise in the female dog’s body, triggering hormonal changes that cause bleeding.

In some cases, heat cycles can be induced by injecting the dog with P.G. 600®, a synthetic form of Progesterone initially developed for pigs.

Besides inducing estrus, PG 600 can also help to dissolve any scar tissue on the ovaries. While it is not always successful, PG 600 injections offer a potential solution for dogs who do not experience regular heat cycles or experiencing irregular cycles. 

Remember that PG 600 are not specially formulated injections for dogs. So it would be best if you were careful when using the injections for your pooch.

This blog article is an Ultimate guide about PG 600 For Dogs, its uses, benefits, safe dosage, side effects, How & When to Use?

PG 600 For Dogs

Dogs Escort Disclaimer: Remember, self-medication is harmful. Use any medicine for your furry friend with your veterinarian’s advice only. 

What is PG 600 for dogs?

P.G. 600® injection is a freeze-dried combination of Pregnant Mare Serum Gonadotropin (PMSG), and Human Chorionic Gonadotropin (HCG) supplied with sterile diluent for reconstitution purposes.

PG 600 for dogs is used to treat irregular dog heat cycles. The PMSG in P.G. 600 helps to stimulate follicular development, while the HCG helps to trigger ovulation.

This product, When used as directed, P.G. 600 is an effective treatment for canines estrus cycles. 

Is PG 600 safe for dogs?

Yes, administrating the PG 600 injection is a safe dosage that is safe for dogs and helps a dog to maintain the heat cycle. Some dogs may show adverse effects to the treatment. So, it’s always best to check with your veterinarian first.

What is the safe PG 600 Dosage for dogs?

According to veterinarians and pet experts, the ideal dosage of PG 600 injections for dogs is 0.1 cc/kg or 0.05 cc/lb, Which means that a 9 kg or 20 lbs dog can take 1cc or 1 ml P.G 600.

You need to remember, you should wait for five days for the second dose after administrating the first dose.

Then take a break of 7 days before administrating the 3rd dose, then seven days break and then the 4th dose, and then follow the safe time gap for all the doses your veterinarian prescribes.

PG 600 Dosage Chart for dogs by weight

Weight Dog Kg (0.1 cc/kg)Dog Weight lbs (0.05 cc/lb)PG 600 Dosage for Dogs
4 kg8 lbs0.4 cc (ml)
8 kg17 lbs0.8 cc (ml)
12 kg26 lbs1.2 cc (ml)
16 kg35 lbs1.6 cc (ml)
20 kg44 lbs2 cc (ml)
25 kg55 lbs2.5 cc (ml)
30 kg66 lbs3 cc (ml)
35 kg77 lbs3.5 cc (ml)
40 kg88 lbs4 cc (ml)
45 kg99 lbs4.5 cc (ml)

When to use PG 600?

Only use the PG 600 for your dog if your pet has an irregular heat cycle or if you need to induce heat, and if your veterinarian has recommended this treatment.

How to inject pg600 in dogs?

Injecting P.G 600 into your dog needs proper technique and knowledge. In dogs, the treatment should be injected into the location of the pet’s neck behind the ear.

When to stop pg 600 in dogs?

Never overdose your dog on pg 600. Complete the dosage and stop giving the injection after the prescribed prescription.

Remember that stop giving the pg 600 to your canine if you observe swelling and inflammation in the canine vulva or blood in part. 

Take your pet to the vet for a physical checkup.

What are the side effects of PG 600 in dogs?

dogs and injection

The most common side effect of the PG 600 injection in dogs is temporary discomfort at the injection site. In rare cases, more serious side effects may occur, such as an allergic reaction, inflammation, or abscess formation.

However, overdosing can lead to severe side effects such as an increase or decrease in heart rate, organ damage, and seizures and can even be fatal.

If you notice any of these side effects, contact your veterinarian immediately.

 How long does it take for P.G. 600 to work?

P.G. 600 begins to work within 24 hours of injection, and the effects typically last for 3 to 4 days. However, it is essential to note that the exact length of time that P.G. 600 remains effective may vary depending on the individual animal.


According to the manufacturer, P.G. 600 will not induce estrus in gilts that have already reached puberty and begun to cycle. It is important to note that the delayed return to estrus is most prevalent after the first litter; however, the effectiveness of P.G. 600 has not been established after the last litters.

Also, delayed return to estrus often occurs during adverse environmental conditions, and sows mated under such conditions may farrow smaller than average litters.

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