Sileo For Dogs Dosage Chart By Weight | How To Use?

Dexmedetomidine oromucosal Gel, popular brand name SILEO®, is an FDA-approved gel used to treat noise aversions in dogs, such as fireworks, thunderstorms, traffic, sirens, and other loud noises. 

Sileo is a synthetic alpha-2 adrenoceptor agonist containing the active sedative and pain reliever Dexmedetomidine that can help to keep your pet calm from noise aversion. 

Knowing about the safe Sileo dosage, its benefits and side effects, and how to administer the gel safely to your dog is essential for every canine owner to benefit from and to avoid any adverse reactions.

This blog article is an ultimate guide about Sileo Dexmedetomidine oromucosal Gel for dogs.

Sileo For Dogs

Dogs Escort Disclaimer: The information in this article should be used for guidance purposes only and will never replace your veterinarian’s advice. Self-use of Sileo is Forbidden. Federal law of the united states restricts the treatment to use by or on the order of a licensed veterinarian only. The aim of the article is to guide our readers not to review a product.

Sileo For Dogs Dosage

According to Zoetis, the recommended dosage of Sileo for dogs is 125 mcg/m2 at the oral mucosa between the dog’s cheek and gum. This means you can apply 0.25ml (1 Dot) of the gel to a dog having a body weight of 2 kg to 5.4 kg. In the dosing syringe of the Sileo, one dot means 0.25 ml gel.

Sileo For Dogs Dosage

Each ml of Sileo contains 0.09 mg dexmedetomidine (0.1mg dexmedetomidine hydrochloride)

For the best result, give this  Dexmedetomidine oromucosal Gel approximately 30-60 minutes before any noise events, such as fireworks, thunderstorms, etc., or administer the dose if you observe any signs of noise anxiety in your puppy dog.

You should never exceed for more than 5 times a day and make sure to keep a gap of at least 2 hours between the parallel doses. 

Sileo Dosage Chart  for dogs by weight

Dog Weight kgDog Weight lbsSileo (Dexmedetomidine) Dosage in mlSileo  Dosage in dots 
2 kg – 5.4 kg4.4 lbs -12.1 lbs0.25 ml1 dot
5.5 kg-12 kg12.2 lbs – 26.5 lbs0.5 ml2 dots
12.1 kg – 19.926.6 lbs – 44 lbs0.75 ml3 dots
20 kg – 28.9 kg44.1 lbs – 63.9 lbs1 ml4 dots
29 kg – 39 kg64 lbs – 86 lbs1.25 ml5 dots
39.1 kg – 49.9 kg86.1 lbs – 110.2 lbs1.5 ml6 dots
50 kg – 62.5 kg110.3 lbs – 137.8 lbs1.75 ml7 dots
62.5kg – 74.5 kg137.9 lbs – 166.4 lbs2 ml8 dots
75.5 kg – 88.9 kg166.5 lbs – 196.2 lbs2.25 ml9 dots
89 kg – 100 kg196.3 lbs – 220.5 lbs2.5 ml10 dots

How does Sileo Gel work in dogs?

SILEO® contain the active ingredients Dexmedetomidine which absorbs through the mucous membranes in the mouth and start its sedative effect within 30 min to 1 hour.

Once the Dexmedetomidine, this synthetic alpha-2 adrenoceptor agonist inhibits the release of noradrenaline from noradrenergic neurons and helps to keep your pet calm from the noise anxiety.

Is sileo safe for dogs?

Yes, administrating the sileo in the correct dosage to your dog can help to prevent your pet from noise, fear, or anxiety and will keep them calm during such situations.

However, you can not use the oral gel in some dogs that are mentioned in this article below.

Uses of Sileo in Dogs

Sileo Dexmedetomidine oromucosal Gel can be used for the prevention of noise anxiety or noise fear caused by:

  • 1) Fireworks
  • 2) Thunderstorms
  • 3) Sirens and doorbells
  • 4) Indoor or Outdoor construction noises
  • 5) Loud music, indoor or outdoor
  • 6) Loudspeaker sounds
  • 7) Household essential tools sound such as lawn mowers or drills etc.
  • 8) Other Loud sounds or noises. 

How to Administer?

Remember that you can only administer the SILEO gel to a dog’s oral mucosa in a location between the dog’s cheek and gum because the gel is helpful when absorbed in the oral mucosa. 

You must be aware that this product is not suitable to be swallowed. If your pooch accidentally swallows the gel, don’t give two parallel doses at a time. Wait for fot at least two hours before administrating the second dose.

Always ensure to wear disposable gloves and use a SILEO syringe for the accurate dosage. 

To prevent overdosing, lock the ring stop of the syringe prior to administration. This is best to keep pregnant women away from administering or handling the SILEO. 

Which dogs should not use Sileo Gel?

 Sileo (Dexmedetomidine oromucosal Gel) is not safe for all dogs.

Do not use the treatment for canines having health issues such as kidney or liver illness, cardiovascular, respiratory issues, seizures, severe debilitation, conditions of shock, severe debilitation, stress due to extreme heat, cold or fatigue, and dogs allergic or hypersensitivity to the Dexmedetomidine. 

Don’t give the Sileo to Puppies that weigh less the 2 kg without a vet prescription. 

In how much time does Sileo start its effect?

Usually, Sileo takes about 30min – 60 min to start its effect once absorbed in the mucous membranes. In some dogs that are pond to use other sedatives, Sileo can take a long to start its work.

How long does sileo last in dogs?

Sileo will remain effective in dogs for approximately 2-3  hours. If noise events take longer than this, you can give the next dose to your pet and can continue the dosage with a time gap of 2 hours according to the event duration but not exceed five doses. 

Sileo side effects of for dogs

The commonly reported side effects of the sileo in dogs are:

  • Vomiting
  • Diarrhea
  • Decrease Heart rate
  • Weakness
  • Irregular breathing
  • Drowsiness
  • Lethargy 

Can I overdose my dog on sileo?

No, never overdose your dog on sileo. Overdosing of Dexmedetomidine can be toxic if your puppy swallows it in an excessive amount and can lead to minor or severe health complications. 

Sileo Instructions

All the credit for the below-mentioned Sileo Instruction goes to its original manufacturer Zoetis.

Image Credit: Zoetis

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