Trazodone For Dogs: Dosage Chart by Weight

Trazodone is a medication that is often used to treat human anxiety and depression, and it turns out that it can be safely used in dogs as well. If you’re a dog owner, you know that pets can suffer from anxiety and stress like people.

While there are many different medications available for humans to help with these conditions, not all are safe for canines.

This post will discuss Trazodone for dogs, how it works, and how it can help relieve your dog’s anxiety.

We’ll also cover the benefits and some of the potential side effects so that you can decide if this medication is right for your pet or not.

Trazodone for Dogs

What is Trazodone for Dogs?

50mg Trazodone for dogs

Trazodone is a medication that belongs to the class of drugs known as antidepressants. It’s often used to treat human anxiety and depression.

For dogs, trazodone has been found to be an effective treatment for anxiety disorders.

The drug enhanced behavioral calmness and reduced stress levels while improving patient welfare with few side effects.

In canines The trazodone is mainly used to treat:

Trazodone works by increasing serotonin levels in the brain, which helps to improve mood and reduce canine anxiety.

Trazodone Dosage for Dogs

Trazodone Dosage for Dogs

The safe and recommended Trazodone dosage for dogs is 2.5 mg/kg to 3.5mg/kg or 1.5/lbs to 2.5/lbs 1 time daily. However, the dose can be increased to 10mg-12mg/lb with a veterinarian’s advice on certain issues.

The ideal dose of any canine medication depends on certain factors, including the pup’s body weight, the severity of the health problem, breed, and overall health condition.

If you’re considering giving your dog trazodone, it’s essential to talk to your veterinarian first.

They can help you determine if this medication is right for your puppy and will also provide more information on the proper dosage and potential side effects.

Dosage Calculator

Trazodone Dosage Chart for Dogs by Weight

Dog Weight in lbsDog Weight in kg Trazadone dosage for dogs
5-10 lb2-5 kg 5-15 mg
10-20 lb5-10 kg 12-25 mg
20-30 lb10-15 kg 25-45 mg
30-40 lb13-18 kg 30-55 mg
40-50 lb18-22 kg 45-65 mg
50-60 lb22-27 kg 55-85 mg
60-70 lb27-31 kg 67-95 mg
70-80 lb31-36 kg 77-110 mg
80-90 lb36-40 kg 90-140mg
100+ lb45+ kg 112-200mg
Dog Weight50mg Trazodone Tablet Dosage
5-10 lb¼ Tablet 
10-20 lb½ Tablet
20-30 lb1 Tablet
30-40 lb1 ½ Tablet
40-50 lb2 Tablets
50-60 lb2 Tablets
60-70 lb2 Tablets
70-80 lb2 ½ Tablets
80-90 lb2 ½ Tablets
100+ lb3 Tablets
Dog Weight100mg Trazodone Tablet Dosage for dogs
5-10 lb⅛  Tablet 
10-20 lb¼  Tablet
20-30 lb½  Tablet
30-40 lb½  Tablet
40-50 lb1 Tablets
50-60 lb1 Tablets
60-70 lb1 Tablets
70-80 lb1 ½ Tablets
80-90 lb1 ½ Tablets

How does Trazodone work for dogs?

Trazodone works by increasing serotonin levels in the brain. Serotonin is a neurotransmitter that helps to regulate mood and anxiety.

By increasing serotonin levels, Trazodone can help to improve your dog’s mood and reduce their anxiety.

Please remember that puppies below 2 kg of body weight should only use Trazodone with the veterinarian’s advice. 

Trazodone Side Effects in dogs

Trazodone may have some side effects, including minor to severe. Below are some of the possible side effects of Trazodone for canines.

dog with tablets

1) Dry mouth
2) Drowsiness
3) Constipation
4) Dizziness
5) Lightheadedness
6) Headache
7) Urinary retention,
8) Hypotension

How long does it take for Trazodone to start work for a dog?

Some dogs may begin to show signs of improvement within 1-2 hours after taking trazodone, while others may not improve for several hours. If you don’t see any improvement in your pet’s condition after 4-5 hours, it is something you need to concern about. Contact your veterinarian.

How long does Trazodone last in dogs?

Trazodone typically lasts for around 12 to 24 hours in dogs. However, this can vary depending on the individual dog’s metabolism and other factors. Canines with kidney or liver illnesses may metabolize the drug more slowly, making it last longer in their system.

How does Trazodone make dogs feel?

Trazodone is a medication that is used to treat various conditions in dogs. It can be used to treat canine anxiety, stress, and even aggression. Trazodone works by affecting the puppy brain’s neurotransmitters, which are chemicals that help regulate mood and behavior.

When given to a dog, Trazodone can help to reduce anxiety and calm them down. It is important to note that trazodone should not be used as a sole form of treatment for any condition and should always be used under the guidance of a veterinarian.

How much Trazodone calms a dog?

It is typically recommended that dogs be given 2-3 milligrams of Trazodone per pound of body weight to calm them. Therefore, if your furry friend weighs 50 pounds, you would give them 100-150 milligrams of trazodone.

However, the amount of Trazodone required to calm a dog may vary depending on the individual dog’s size, breed, age, health condition, and other factors.

It is always best to speak with your veterinarian before giving your dog any medication, including Trazodone.

Is Trazodone for dogs the same as Trazodone for Humans?

The short answer is yes, Trazodone for dogs is the same as Trazodone for humans. The active ingredient in both formulations is trazodone hydrochloride. However, there are some essential differences to be aware of.

For starters, the dosage of trazodone for puppies is much lower than the dosage for humans. Secondly, Trazodone for dogs is usually given as an oral tablet, while Trazodone for humans is available as both an oral tablet and an injectable form.

Trazodone for canines is typically used to treat anxiety or behavioral issues, while Trazodone for humans is used mainly as an antidepressant.

Therefore, it’s essential to talk to your veterinarian before giving your dog trazodone to ensure it is the proper medication for your pet’s individual needs.

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Can Trazodone Hurt dogs?

The safe dose of Trazodone will not hurt your pup; however, rarely dogs have other health issues and are allergic to the medication, and overdosing may lead to experiencing side effects after taking Trazodone.

Trazodone is not an FDA-approved medication for canines; however, veterinarians worldwide use it as OTC, and it also works fine on many occasions.

Can I give my dog 100mg of Trazodone?

The best idea to give your dog 50mg trazodone or 100mg trazodone is to crush the tablets to the safe and ideal dose for your puppy.

The maximum dosage of Trazodone for dogs has not been established, but some anecdotal evidence suggests dogs have received up to 200mg/day without serious side effects.

I recommend close monitoring if you choose to go above the 100mg/day dose.

Is 200 mg of Trazodone safe for dogs?

200mg of Trazodone is safe for dogs weight 50kg or above. If your pup is less the 45 kilograms, do not give the 200mg Trazodone. Make sure to cut the tablet into pieces to the safe dosage of trazodone for your puppy.

When should you give your dog Trazodone before going to the vet?

If your dog is anxious or nervous about going to the vet, you may want to give them a dose of Trazodone before the appointment. You can provide Trazodone to your pet 2-3 hours before a vet visit. This will help to calm your puppy and make the experience less stressful.


For dogs, Trazodone is an effective medication to treat anxiety; however, the medicine may interact with other medications, so tell your veterinarian about any other medications your dog is taking before starting Trazodone.

Do not stop giving Trazodone suddenly without talking to your veterinarian first, which can cause serious side effects.

If your dog has a liver or kidney disease history, please check with your veterinarian before starting this medication. Trazodone may not suit all dogs, and some medical conditions may interact with this drug.

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Trazodone dosage chart for dogs

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