Trilostane with the brand name VETORYL® is an FDA-approved veterinary medication used to treat pituitary-dependent Hyperadrenocorticism (PDH) and adrenal-dependent hyperadrenocorticism (ADH).
Giving your dog the correct dosage of Trilostane (VETORYL®) is essential for their health and can be tricky if you’re unsure how much to provide them with.
This blog post will cover everything you need about Trilostane for veterinary use, including dosage, benefits, side effects, when and how to give it to a dog, and more.
Dogs Escort Disclaimer: Self-medication and administrating Trilostane in the wrong dosage to the wrong dog can be fatal. Seek your vet advice.
Trilostane Dosage For Dogs
The recommended Trilostane Dosage For the treatment of hyperadrenocorticism in dogs is 2.2-6.7 mg/kg (1-3 mg/lb) once daily, following your veterinarian prescribed duration.
To prevent complications, it is best to always start with the lower dose according to the body weight and then gradually increase to the recommended dosage.
Remember, after using the Trilostane therapy for approximately 10-14 days at the above dose for your canine.
For further use, first, re-examine your pet and conduct a 4-6 hour post-dosing ACTH stimulation test along with serum biochemical tests with a focus on renal and hepatic function and electrolytes.
If the test result is normal and your dog is ok for further therapy, follow the mentioned guidelines for further use mentioned in the table below.
Remember: This information is based on the Trilostane brand name VETORYL®. If you are using any other brand of Trilostane for your furry friends, follow your vet’s advice and the instructions according to the manufacturer’s guidelines.
Vetoryl Trilostane Dosage For Dogs
| Weight kg (2.2-6.7 mg/kg) | Weight in lbs (1-3 mg/lb) | Vetoryl Trilostane Dose For dog (Once daily) |
|---|---|---|
| 5 kg | 11 lbs | 11mg-30 mg |
| 10 kg | 22 lbs | 22mg-65 mg |
| 15 kg | 33 lbs | 33mg-100 mg |
| 20 kg | 44 lbs | 44mg-130mg |
| 25 kg | 55 lbs | 55mg-165 mg |
| 30 kg | 66 lbs | 66 mg-200mg |
| 35 kg | 77 lbs | 77mg-230mg |
| 40 kg | 88 lbs | 88mg-260mg |
| 45 kg | 99 lbs | 99mg-300mg |
| 50 kg | 110 lbs | 110-330mg |
| Weight Dog kg (2.2-6.7 mg/kg) | Vetoryl 5mg Dosage | Vetoryl 10mg Dosage | Vetoryl 30mg Dosage | Vetoryl 60mg Dosage | Vetoryl 120mg Dosage |
|---|---|---|---|---|---|
| 3 kg | 1 cap | * | * | * | * |
| 5 kg | 2 cap | 1 cap | * | * | * |
| 10 kg | * | 2 cap | 1 cap | * | * |
| 15 kg | * | 2 cap | 1 cap | * | * |
| 20 kg | * | * | 2 cap | 1 cap | * |
| 25 kg | * | * | 2 cap | 1 cap | * |
| 30 kg | * | * | * | 2 cap | 1 cap |
| 35 kg | * | * | * | 2 cap | 1 cap |
| 40 kg | * | * | * | * | 1 cap |
| 45 kg | * | * | * | * | 1 to 2 cap |
| 50 kg | * | * | * | * | 1 to 2 cap |
Side Effects of Trilostane in Canines
The most common side effects of Trilostane in dogs are vomiting, diarrhea, lethargy, loss of appetite, and increased thirst and urination. Less common side effects include panting, shaking, or tremors.
Severe Side Effects of Trilostane are:
- Weakness
- Lethargy
- Anorexia
- Depression
- Elevated creatinine
- Elevated liver enzymes
- Elevated potassium
- Decreased Na/K ratio,
- Hypoadrenocorticis
- Renal issues
- Death
Contact your veterinarian immediately if your dog experiences any of these side effects.
Which dogs should not take Trilostane?
There are a few conditions that would make Trilostane an unsuitable treatment for your pet.
Dogs with primary hepatic or renal disease and pregnant dogs who have Addison’s disease or Cushing’s disease should not take Trilostane.
Canines who are taking other medications that affect the adrenal gland (such as prednisone) should not take Trilostane.
Canine hypersensitive or allergic to the medicine, and puppies weight below 3 kg or aged below four months should only take medicine with the veterinarian’s advice only.
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