Trilostane Dosage For Dogs | VETORYL Explained

Trilostane with the brand name VETORYL® is an FDA-approved veterinary medication used to treat pituitary-dependent Hyperadrenocorticism (PDH) and adrenal-dependent hyperadrenocorticism (ADH).

Giving your dog the correct dosage of Trilostane (VETORYL®) is essential for their health and can be tricky if you’re unsure how much to provide them with.

This blog post will cover everything you need about Trilostane for veterinary use, including dosage, benefits, side effects, when and how to give it to a dog, and more.

Trilostane Dosage For Dogs

Dogs Escort Disclaimer: Self-medication and administrating Trilostane in the wrong dosage to the wrong dog can be fatal. Seek your vet advice.

Trilostane Dosage For Dogs

The recommended Trilostane Dosage For the treatment of hyperadrenocorticism in dogs is 2.2-6.7 mg/kg (1-3 mg/lb) once daily, following your veterinarian prescribed duration.

To prevent complications, it is best to always start with the lower dose according to the body weight and then gradually increase to the recommended dosage.

Trilostane for dogs

Remember, after using the Trilostane therapy for approximately 10-14 days at the above dose for your canine.

For further use, first, re-examine your pet and conduct a 4-6 hour post-dosing ACTH stimulation test along with serum biochemical tests with a focus on renal and hepatic function and electrolytes. 

If the test result is normal and your dog is ok for further therapy, follow the mentioned guidelines for further use mentioned in the table below.

Remember: This information is based on the Trilostane brand name VETORYL®. If you are using any other brand of Trilostane for your furry friends, follow your vet’s advice and the instructions according to the manufacturer’s guidelines.

Image Source: Dechra – Exclusively for veterinarians worldwide (

Vetoryl Trilostane Dosage For Dogs

Weight kg (2.2-6.7 mg/kg)Weight in lbs (1-3 mg/lb)Vetoryl Trilostane Dose For dog (Once daily)
5 kg11 lbs11mg-30 mg
10 kg22 lbs 22mg-65 mg
15 kg33 lbs33mg-100 mg
20 kg44 lbs44mg-130mg
25 kg55 lbs55mg-165 mg
30 kg66 lbs66 mg-200mg
35 kg77 lbs 77mg-230mg
40 kg88 lbs88mg-260mg
45 kg99 lbs99mg-300mg
50 kg110 lbs110-330mg
Weight Dog kg (2.2-6.7 mg/kg)Vetoryl 5mg DosageVetoryl 10mg DosageVetoryl 30mg DosageVetoryl 60mg DosageVetoryl 120mg Dosage
3 kg1 cap****
5 kg2 cap1 cap***
10 kg*2 cap1 cap**
15 kg*2 cap1 cap**
20 kg**2 cap1 cap*
25 kg**2 cap1 cap*
30 kg***2 cap1 cap
35 kg***2 cap1 cap
40 kg****1 cap
45 kg****1 to 2 cap
50 kg****1 to 2 cap

Side Effects of Trilostane in Canines

The most common side effects of Trilostane in dogs are vomiting, diarrhea, lethargy, loss of appetite, and increased thirst and urination. Less common side effects include panting, shaking, or tremors.

Severe Side Effects of Trilostane are:

  • Weakness
  • Lethargy
  • Anorexia
  • Depression
  • Elevated creatinine
  • Elevated liver enzymes
  • Elevated potassium
  • Decreased Na/K ratio,
  • Hypoadrenocorticis
  • Renal issues
  • Death

Contact your veterinarian immediately if your dog experiences any of these side effects.

Which dogs should not take Trilostane?

There are a few conditions that would make Trilostane an unsuitable treatment for your pet.

Dogs with primary hepatic or renal disease and pregnant dogs who have Addison’s disease or Cushing’s disease should not take Trilostane.

Canines who are taking other medications that affect the adrenal gland (such as prednisone) should not take Trilostane.

Canine hypersensitive or allergic to the medicine, and puppies weight below 3 kg or aged below four months should only take medicine with the veterinarian’s advice only.

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