Tylosin popular brand name Tylan® is a macrolide antibiotic medicine commonly used to treat intestinal bacteria, diarrhea, colitis, IBD, tear-staining, soft tissue infections, and respiratory infections in dogs.
Generally, Tylosin is a natural antibiotic primarily made of bacteria that promotes and maintains canines intestinal flora while suppressing suppressing harmful bacteria, limiting and killing bacteria by inhibiting the production of proteins.
Tylosin (Tylan®) is not an FDA-approved medicine for dogs; however, the drug is legally prescribed by veterinary off-label around the world.
To avoid any complications, this is essential for every canine owner to know about the safe dosage, safety precautions, side effects, and safe ways of administration.
This article is a comprehensive guide about (Tylan®) Tylosin for dogs, including a dosage calculator and dosage chart by weight.

Tylosin Dosage For Dogs
The ideal dosage of Tylosin for dogs is 10-20 mg/kg (5-10 mg/lb) every 12 hours. The dosage of Tylan 50 mg/ml Injectable in dogs is 0.2 ml/kg and of 200 mg/ml is 0.05 ml/kg.
Each ml of Tylosin 100g Soluble contains 0.54 gm Tylosin. The dosage of Tylosin 100g Soluble for dogs is 0.04 ml/kg. This means a 25 kg dog can take 1 ml of the Tylosin 100g Soluble.

The drug dosage for your puppy can be increased or decreased depending on the health issues being treated, with your veterinarian’s advice only.
Remember that Tylosin oral and Tylosin liquid require different prescriptions, so follow your veterinarian’s advice.
Tylosin Dosage Chart For Dogs
Dog Weight | Dog Weight | Tylan® Liquid Injectable Dosage |
---|---|---|
3 kg | 7 lbs | 30-60 mg |
5 kg | 11 lbs | 50-100 mg |
8 kg | 17 lbs | 80-160 mg |
10 kg | 22 lbs | 100-200 mg |
15 kg | 33 lbs | 150-300 mg |
20 kg | 44 lbs | 200-400 mg |
25 kg | 55 lbs | 250-500 mg |
30 kg | 66 lbs | 300-600 mg |
40 kg | 88 lbs | 400-800 mg |
50 kg | 110 lbs | 500-1000 mg |
Tylan® Liquid Injectable Dosage Chart For Dogs
Dog Weight | Tylan 50 mg/ml Injectable Dosage (0.2 ml/kg) | Tylan 200 mg/ml Injectable Dosage (0.05 ml/kg) |
---|---|---|
3 kg | 0.6 ml | 0.15 ml |
5 kg | 1 ml | 0.25 ml |
8 kg | 1.6 ml | 0.4 ml |
10 kg | 2 ml | 0.5 ml |
15 kg | 3 ml | 0.75 ml |
20 kg | 4 ml | 1 ml |
25 kg | 5 ml | 1.25 ml |
30 kg | 6 ml | 1.5 ml |
40 kg | 8 ml | 2 ml |
50 kg | 10 ml | 2.5 ml |
Tylosin 100g Soluble For Dogs
kg Weight Dog | Dog Weight lbs | Tylosin 100g Soluble Dosage For Dogs |
---|---|---|
5 kg | 11 lbs | 0.2 ml |
10 kg | 22 lbs | 0.4 ml |
15 kg | 33 lbs | 0.6 ml |
20 kg | 44 lbs | 0.8 ml |
25 kg | 55 lbs | 1 ml |
30 kg | 66 lbs | 1.2 ml |
40 kg | 88 lbs | 1.6 ml |
50 kg | 110 lbs | 2 ml |
60 kg | 132 lbs | 2.4 ml |
70 kg | 154 lbs | 2.8 ml |
Dosage Calculator
Common Uses of Tylosin In Canines
The Drug is used to treat:
- Chronic diarrhea
- Clostridium perfringens diarrhea
- Colitis
- Intestinal bacteria
- Inflammatory bowel disease
- Respiratory tract infections
- Soft tissues infection
- Skin infections
- Tear-staining
Possible Side Effects:
Reported side effects of using Tylosin in dogs are:
- Gastrointestinal Upset
- Decreased appetite
- Vomiting & Diarrhea
- Mouth Foaming
- Growling
- Protrusion on anus
- Pain and inflammation in the injection area
Which dogs should not take Tylosin?
Dogs having a known hypersensitivity or allergy should not use Tylosin. Pregnant, nursing and canine having other severe complications such as kidney and liver issues should not take the drug without consulting a veterinarian first.
Puppies weight less then 3 kg use the treatment with the vet advice only.
In how much time does Tylosin start its effect?

In dogs, Tylan starts its effects within 1-2 hours. The injectable form starts its effects more quickly than the oral form. In some canines, the effect may start quickly and vice versa.
Which drugs should not be used parallel with Tylosin?
Certain drugs, including digoxin, Lincosamides and Chloramphenicol, may interact with Tylosin. Let your vet know if your puppy is on any of the mentioned treatments.
How to give tylosin to your pet?
Tylosin power has a very bitter taste and may cause excessive foaming in your dog’s mouth.
You can give the powder from tylosin by packing it in the capsule. The powder and liquid form can be given with or without food.
The best way is to give the treatment with a safe version of the canine diet.
Tylosin injection can be administrated IM under the supervision of the veterinarian.
How long should a dog take Tylosin?
The treatment duration on Tylosin depends on the severity of the health issues and dogs overall performance to the medicine.
However in general a dog can continue taking the drugs from 7-14 days.
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